Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Diaminobenzoic acid → 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Diaminobenzoic acid | HCID 198069 | — |
| 반응물 | 2-Methylpyridine-3-carbaldehyde | HCID 11083881 | — |
| 생성물 | 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid | HCID 67201388 | — |
반응 단계
2-Methylnicotinaldehyde (149; 2.18 g, 18 mmol) was subjected to the standard conditions used to prepare substituted benzimidazoles by reaction with 2,3-diaminobenzoic acid 1. The desired product, 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid 150, was obtained by purification using chromatography, followed by crystallization from EtOAc (0.43 g, 11%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846947B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-a9508b06c04a4fd9872ce6c2ef014089 |
| 출처 메모 | uspto-grants-2014_09 |