2,3-Diaminobenzoic acid → 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid

HRID 85185

반응식

HRID 85185 반응식
[CH3:1][C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[NH2:10][C:11]1[C:19]([NH2:20])=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]>>[CH3:1][C:2]1[C:3]([C:4]2[NH:20][C:19]3[CH:18]=[CH:17][CH:16]=[C:12]([C:13]([OH:15])=[O:14])[C:11]=3[N:10]=2)=[CH:6][CH:7]=[CH:8][N:9]=1

참가 물질

3

반응물 2

HCID 1980692,3-Diaminobenzoic acidHCID 110838812-Methylpyridine-3-carbaldehyde

생성물 1

HCID 672013882-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid

실험 절차

2-Methylnicotinaldehyde (149; 2.18 g, 18 mmol) was subjected to the standard conditions used to prepare substituted benzimidazoles by reaction with 2,3-diaminobenzoic acid 1. The desired product, 2-(2-methylpyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid 150, was obtained by purification using chromatography, followed by crystallization from EtOAc (0.43 g, 11%).

출처 및 근거

ORD 기록
ord-a9508b06c04a4fd9872ce6c2ef014089
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846947B2

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