Water → HCID 12157386, 화합물

HRID 851880노트

반응식

HRID 851880 반응식
B(Br)(Br)Br.[CH3:5][O:6][C:7]1[CH:21]=[CH:20][C:10]2[N:11]3[CH2:19][CH2:18][CH2:17][C:12]3=[N:13][S:14](=[O:16])(=[O:15])[C:9]=2[CH:8]=1.[OH2:22]>C(Cl)Cl>[O:15]=[S:14]1(=[O:16])[C:9]2[CH:8]=[C:7]([O:6][C:5]3[CH:9]=[C:8]([OH:22])[CH:7]=[CH:21][CH:20]=3)[CH:21]=[CH:20][C:10]=2[N:11]2[CH2:19][CH2:18][CH2:17][C:12]2=[N:13]1

참가 물질

5

반응물 3

HCID 962WaterHCID 25134Boron tribromideHCID 11253769HCID 11253769, 화합물

생성물 1

HCID 12157386HCID 12157386, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 68.75 mmol of BBr3 in 25 ml of methylene chloride is added dropwise to a solution, cooled to 0° C., of 27.50 mmol of 7-methoxy-2,3-dihydro-1H-pyrrolo-[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide in 350 ml of methylene chloride. Stirring is carried out at ambient temperature for 24 hours. The reaction mixture is poured into a mixture of ice and water, and the suspension is stirred for 30 minutes. The precipitate is filtered off, rinsed several times with water, filtered under suction and dried in vacuo to yield the expected product.

후처리

  1. stirringthe suspension is stirred for 30 minutes
  2. filtrationThe precipitate is filtered off
  3. washrinsed several times with water
  4. filtrationfiltered under suction
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-c1eaf65283c048ba94d3cea6f186348b
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253163B2

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