1,1'-Carbonyldiimidazole → 4-Phenylbutyl perhydropyridazinecarboxylate

HRID 851940노트

반응식

HRID 851940 반응식
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[C:13]1([CH2:19][CH2:20][CH2:21][CH2:22][OH:23])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[NH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][NH:25]1>C(Cl)Cl>[NH:24]1[CH2:29][CH2:28][CH2:27][CH:26]([C:1]([O:23][CH2:22][CH2:21][CH2:20][CH2:19][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:2])[NH:25]1

참가 물질

5

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 76889BenzenebutanolHCID 1363341,2-Diazinane

생성물 1

HCID 184700714-Phenylbutyl perhydropyridazinecarboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution containing 1,1′carbonyl diimidazole (0.893 g, 5.5 mmol) in 5 ml CH2Cl2 was added slowly to a solution of CH2Cl2 containing phenylbutyl alcohol (0.89 ml, 5.77 mmol). After stirring at room temperature for 1 hour, this solution was then added slowly to a solution containing perhydropyridazine mentioned above. The reaction was allowed to stir for overnight. The crude mixture was then concentrated and used without further purification.

후처리

  1. additionthis solution was then added slowly to a solution
  2. stirringto stir for overnight
  3. concentrationThe crude mixture was then concentrated
  4. customused without further purification

출처 및 근거

ORD 기록
ord-a45f4825d1b644e09ccfb89885227551
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253169B2

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