Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(4-Fluorophenoxy)piperidine → (R)-1-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-[4-(4-fluoro-phenoxy)-piperidin-1-yl]-propan-2-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(4-Fluorophenoxy)piperidine | HCID 3734896 | — |
| 반응물 | (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole | HCID 58928269 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (R)-1-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-3-[4-(4-fluoro-phenoxy)-piperidin-1-yl]-propan-2-ol | HCID 9826447 | — |
반응 단계
The title compound is prepared from a mixture of (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 4-(4-fluoro-phenoxy)-piperidine (Table No.1, SM 5) in ethanol essentially as described above in Example 21. Purity by LC/MS=86%, [M+H]+=481 and 8%, [M+H]+=573.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07253165B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-cccd97cacbbc46d58b30b2b14a611fe6 |
| 출처 메모 | uspto-grants-2007_08 |