Dimethylformamide → (S)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol

HRID 852131

반응식

HRID 852131 반응식
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.[CH3:22][N:23]([CH3:26])C=O>C1C2C(=CC=CC=2)CCN1.C(O)C>[CH2:22]1[C:20]2[C:5](=[CH:4][CH:3]=[CH:2][CH:21]=2)[CH2:6][CH2:26][N:23]1[CH2:19][C@H:17]([OH:18])[CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([C:6]2[C:5]3[CH:20]=[CH:21][C:2]([F:1])=[CH:3][C:4]=3[O:8][N:7]=2)=[CH:10][CH:11]=1

참가 물질

5

반응물 2

HCID 6228DimethylformamideHCID 11254641(S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

생성물 1

HCID 9823314(S)-1-(3,4-dihydro-1H-isoquinolin-2-yl)-3-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-phenoxy]-propan-2-ol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 70461,2,3,4-Tetrahydroisoquinoline용매

실험 절차

The title compound is prepared from a mixture of (S)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole in dimethylformamide and 1,2,3,4-tetrahydroisoquinoline in ethanol essentially as described above in Example 21. Purity by LC/MS=98%, [M+H]+=419.

출처 및 근거

ORD 기록
ord-048dda65d4d14529a240203862be4073
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253165B2

연결된 노트

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