Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Iodide → 2-[3-(2-Methyl-2-nitropropyl)imidazo[1,2-a]pyridin-7-yloxy]-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Chloroacetamide | HCID 6580 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | HCID 178441236 | HCID 178441236 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | 2-[3-(2-Methyl-2-nitropropyl)imidazo[1,2-a]pyridin-7-yloxy]-acetamide | HCID 22038569 | 34.3% |
반응 단계
3-(2-Methyl-2-nitropropyl)imidazo[1,2-a]pyridin-7-ol (1.5 g, 6.38 mmol), chloroacetamide (1.19 g, 12.73 mmol), potassium carbonate (6.4 mmol) and a small amount of potassium iodide in 2-butanone (30 ml) is heated at reflux overnight. The solids are removed by filtration and the filtrate is concentrated under reduced pressure. The residue is chromatographed on silica gel with dichloromethane/methanol 3:1 to 1:1 to give 640 mg of 2-[3-(2-methyl-2-nitropropyl)imidazo[1,2-a]pyridin-7-yloxy]-acetamide (34%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07253181B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-5c849ac6426645c392d44416bed12283 |
| 출처 메모 | uspto-grants-2007_08 |