Sodium Iodide → Benzene, 1-(4-iodo-1-butyn-1-yl)-4-(trifluoromethyl)-

HRID 852359노트

반응식

HRID 852359 반응식
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:8]=[CH:7][C:6]([C:9]#[C:10][CH2:11][CH2:12]OS(C)(=O)=O)=[CH:5][CH:4]=1.[Na+].[I-:21]>CC(=O)CC>[I:21][CH2:12][CH2:11][C:10]#[C:9][C:6]1[CH:7]=[CH:8][C:3]([C:2]([F:19])([F:18])[F:1])=[CH:4][CH:5]=1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 86602536Methanesulfonic acid 4-(4-trifluoromethyl-phenyl)-but-3-ynyl ester

생성물 1

HCID 69458210Benzene, 1-(4-iodo-1-butyn-1-yl)-4-(trifluoromethyl)-수율 98.8%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

반응 조건

온도
90 °C

실험 절차

To a solution of 3.16 g (10.81 mmol) methanesulfonic acid 4-(4-trifluoromethyl-phenyl)-but-3-ynyl ester in 100 ml 2-butanone was added 3.24 g (21.62 mmol) NaI. The mixture was heated for 2 h at 90° C. The solvent was evaporated and the residue suspended in dichloromethane, ether was added and the suspension was filtrated. Evaporation of the organic phase gave 3.46 g of the title compound as an orange liquid.

후처리

  1. customThe solvent was evaporated
  2. additionether was added
  3. filtrationthe suspension was filtrated
  4. customEvaporation of the organic phase

출처 및 근거

ORD 기록
ord-83e01209fab64aa5b919d9764167e053
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253192B2

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