5-Chloro-2-(trifluoromethyl)pyrimidine → 2-Methyl-2-{2-methyl-4-[5-(2-trifluoromethyl-pyrimidin-5-yl)-pent-4-ynyloxy]-phenoxy}-propionic acid

HRID 852394

반응식

HRID 852394 반응식
Cl[C:2]1[CH:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[N:6][CH:7]=1.[CH3:12][C:13]([O:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][CH2:28][C:29]#[CH:30])=[CH:21][C:20]=1[CH3:31])([CH3:17])[C:14]([OH:16])=[O:15]>>[CH3:17][C:13]([O:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][CH2:28][C:29]#[C:30][C:2]2[CH:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[N:6][CH:7]=2)=[CH:21][C:20]=1[CH3:31])([CH3:12])[C:14]([OH:16])=[O:15]

참가 물질

3

반응물 2

HCID 336979605-Chloro-2-(trifluoromethyl)pyrimidineHCID 86602542HCID 86602542, 화합물

생성물 1

HCID 115318912-Methyl-2-{2-methyl-4-[5-(2-trifluoromethyl-pyrimidin-5-yl)-pent-4-ynyloxy]-phenoxy}-propionic acid

실험 절차

In analogy to the procedure described in example 24E], 5-chloro-2-trifluoromethyl-pyrimidine (example 28B]) and 2-methyl-2-(2-methyl-4-pent-4-ynyloxy-phenoxy)-propionic acid (example 26B]), followed by flash chromatography (SiO2, CH2Cl2/MeOH 2.5 to 10%) and precipitation ether/n-pentane yielded the title compound as white powder, mp. 95-97° C., dec.

후처리

  1. customfollowed by flash chromatography (SiO2, CH2Cl2/MeOH 2.5 to 10%) and precipitation ether/n-pentane

출처 및 근거

ORD 기록
ord-ef705838af9e43dd9761afc4bd26139e
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253192B2

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