Ammonia → 1-(Adamantan-1-yl)thiourea

반응식

[C:1]12([N:11]=[C:12]=[S:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH3:14]>>[C:1]12([NH:11][C:12]([NH2:14])=[S:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

참가 물질

반응물 2

HCID 222Ammonia

HCID 107279Adamantyl isothiocyanate

생성물 1

HCID 7964291-(Adamantan-1-yl)thiourea

실험 절차

A mixture of 1-adamantyl isothiocyanate (4.83 g, 25.0 mmol, Aldrich) and ammonia (0.5 M solution in 1,4-dioxane, 100 mL, 50 mmol) was stirred at ambient temperature for 48 h. The solvents were removed in vacuo to give the title compound as a white solid. MS m/z: 211.1 (M+H)+.

후처리

customThe solvents were removed in vacuo

출처 및 근거

ORD 기록: ord-288db09c604c42359a5d1e34100371d1
출처 데이터셋: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07253196B2

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