Imidazole → 2-Amino-4-(tert-butyldimethylsilanyloxy)butyric acid

HRID 8529

반응식

HRID 8529 반응식
N1C=CN=C1.[NH2:6][C@H:7]([C:11]([OH:13])=[O:12])[CH2:8][CH2:9][OH:10].[Si:14](Cl)([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15].O>CN(C=O)C>[NH2:6][CH:7]([CH2:8][CH2:9][O:10][Si:14]([C:17]([CH3:20])([CH3:19])[CH3:18])([CH3:16])[CH3:15])[C:11]([OH:13])=[O:12]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 962WaterHCID 12647L-HomoserineHCID 28928tert-Butyldimethylsilyl chloride

생성물 1

HCID 220157142-Amino-4-(tert-butyldimethylsilanyloxy)butyric acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Imidazole (20.4 g, 300 mmol) is added to a solution of homoserine (11.9 g, 100 mmol) in DMF (100 mL) and the solution is stirred 15 minutes then cooled to 0° C. tert-Butyldimethylsilyl chloride (13.7 g, 91 mmol) added and the mixture is stirred for ten minutes at 0° C. the for 4 hours at room temperature. The reaction mixture is poured into water (3 L) and the resulting solid is collected by filtration. The isolated product is dried and used without further purification.

후처리

  1. additionadded
  2. stirringthe mixture is stirred for ten minutes at 0° C. the for 4 hours at room temperature
  3. filtrationthe resulting solid is collected by filtration
  4. customThe isolated product is dried
  5. customused without further purification

출처 및 근거

ORD 기록
ord-65bf027c2ce34a99952537c84cd0ebc0
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087759B2

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