Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 852943생성일: 2026년 10월 25일
Potassium Carbonate → 4-[(5-Cyano-2-methylsulfanyl-pyrimidin-4-ylamino)-methyl]-benzoic acid methyl ester
https://huagongshe.com/reaction/852943
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| 반응물 | 4-Amino-2-(methylsulfanyl)pyrimidine-5-carbonitrile | HCID 295757 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 4-[(5-Cyano-2-methylsulfanyl-pyrimidin-4-ylamino)-methyl]-benzoic acid methyl ester | HCID 66622287 | — |
반응 단계
To a solution of 4-amino-2-methylsulfanyl-pyrimidine-5-carbonitrile (229a) (200 mg, 1.2 mmol) in DME (10 ml) were added 4-bromomethyl-benzoic acid methyl ester (274 mg, 1.2 mmol) and K2CO3 (663 mg, 4.8 mmol) at room temperature. The reaction mixture was heated at 100° C. for 5 h, overnight at 60° C., cooled, filtered and concentrated in vacuo. The crude product was used in the next reaction without further purification. LRMS: 314.3(calc.); 315.3 (obt.) (MH)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07253204B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_08 |
|---|
| ORD ID | ord-305f829a2be54efc9c66e8294b34d4a4 |
|---|
| 출처 메모 | uspto-grants-2007_08 |
|---|
