Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (+-)-4-Ethyl-4-[(tosyloxy)methyl]-2-oxazolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | (+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone | HCID 19694098 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | (+-)-4-Ethyl-4-[(tosyloxy)methyl]-2-oxazolidinone | HCID 18968885 | — |
반응 단계
Tosyl chloride (142.2 g, Aldrich) was added to an ice-chilled solution of the product from step (a) (102.7 g) dissolved in pyridine (175 ml. Aldrich). The reaction mixture was stirred at ice bath temperature for six hours, then allowed to come to room temperature. The heterogeneous mixture was added to 1500 ml of a solution of brine and 1N HCl, stirred until solids appeared, filtered and washed with diethyl ether to give 194.6 g of a beige solid as the title product. 1H NMR consistent with the proposed structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723458 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-85a305aeebfc4263a0d5dfa4da2ff2f2 |
| 출처 메모 | uspto-grants-1998_03 |