Water → 5-[1-Quinolin-6-yl-meth-(z)-ylidene]-2-thioxo-thiazolidin-4-one

HRID 853018노트

반응식

HRID 853018 반응식
C(O[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=O)[CH:12]=2)[N:7]=[CH:6][CH:5]=1)C.[S:16]1[CH2:22][C:20](=[O:21])[NH:19][C:17]1=[S:18].O>C(O)(=O)C>[N:7]1[C:8]2[C:13](=[CH:12][C:11](/[CH:14]=[C:22]3/[C:20](=[O:21])[NH:19][C:17](=[S:18])[S:16]/3)=[CH:10][CH:9]=2)[CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 1201546RhodanineHCID 586153616-Quinolinecarboxaldehyde, 4-ethoxy-

생성물 1

HCID 116662315-[1-Quinolin-6-yl-meth-(z)-ylidene]-2-thioxo-thiazolidin-4-one수율 115.7%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The suspension of 4-ethoxy-quinoline-6-carbaldehyde (example 3b) (4.0 g, 20 mmol) and rhodanine (2.65 g, 20 mmol) in acetic acid (40 mL) was stirred under reflux for 12 h. After cooling to room temperature, water (50 mL) was added. The solid was collected by filtration, washed with water and dried to obtain 5-[1-quinolin-6-yl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one (6.3 g, 100%) as a brown solid. LC-MS m/e 317 (MH+).

후처리

  1. temperatureunder reflux for 12 h
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-2edf450a61124f1db998ff09ca44f174
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253285B2

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