Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-3-Bromopropylphthalimide | HCID 21611 | — |
| 반응물 | DMF dimethylformamide | HCID 17824068 | — |
| 반응물 | HCID 178486804 | HCID 178486804 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide | HCID 22936492 | 14.4% |
반응 단계
6,7-Dimethoxy-4-hydroxyquinoline (4.0 g, 19.5 mM), N-(3-bromopropyl)phthalimide (5.8 g, 21.5 mM), potassium carbonate (5.4 g, 39 mM) and DMF dimethylformamide (20 ml) were stirred at 60° C. for 1.5 hours. Water, ethyl acetate and tetrahydrofuran were added to the reaction solution for extraction. The solid which precipitated after standing for a period was filtered out to obtain N-(3-(6,7-dimethoxyquinolin-4-yloxy)propyl)phthalimide (1.1 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07253286B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-2cda75dfc51a483b95bc14dd51552ded |
| 출처 메모 | uspto-grants-2007_08 |