Acetic Acid → HCID 68008943, 화합물

HRID 85328노트

반응식

HRID 85328 반응식
[C:1]([OH:4])(=[O:3])[CH3:2].[CH2:5]([O:12][C:13]1[CH:14]=[C:15]([CH2:19][CH2:20][CH2:21][CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27]O)[CH:16]=[CH:17][CH:18]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>O>[C:1]([O:4][CH2:27][CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21][CH2:20][CH2:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([O:12][CH2:5][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:14]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 680090004-[(3-Benzyloxyphenyl)butylamino]-1-butanol

생성물 1

HCID 68008943HCID 68008943, 화합물수율 88%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

To 10 ml of anhydrous acetic acid was added 2.7 g (8.2 mmol) of 4-[(3-benzyloxyphenyl)butylamino]-1-butanol and the mixture was stirred with heating at 80° C. for 1 hour. The reaction mixture was poured into 150 ml of water and subjected to extraction with ethyl acetate. Washing was performed with a saturated sodium bicarbonate solution and then with a saturated saline solution. Drying over anhydrous sodium sulfate and concentration were performed. The residue was purified by silica gel column chromatography to give 2.68 g of a colorless oily matter (yield: 88.0%).

후처리

  1. extractionsubjected to extraction with ethyl acetate
  2. washWashing
  3. dry with materialDrying over anhydrous sodium sulfate and concentration
  4. customThe residue was purified by silica gel column chromatography
  5. customto give 2.68 g of a colorless oily matter (yield: 88.0%)

출처 및 근거

ORD 기록
ord-c3dd087daabe4927b0368f1600ef1f5d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846955B2

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