1,3-Dibromopropane → n-(4-((7-(3-Bromopropoxy)-6-cyano-4-quinolyl)oxy)-2-chlorophenyl)-n'-cyclopropylurea

HRID 853424노트

반응식

HRID 853424 반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[OH:13])[N:9]=[CH:8][CH:7]=[C:6]2[O:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][CH:25]2[CH2:27][CH2:26]2)=[O:23])=[C:17]([Cl:28])[CH:16]=1)#[N:2].[Br:29][CH2:30][CH2:31][CH2:32]Br>>[Br:29][CH2:30][CH2:31][CH2:32][O:13][C:12]1[CH:11]=[C:10]2[C:5]([C:6]([O:14][C:15]3[CH:20]=[CH:19][C:18]([NH:21][C:22]([NH:24][CH:25]4[CH2:26][CH2:27]4)=[O:23])=[C:17]([Cl:28])[CH:16]=3)=[CH:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[C:1]#[N:2]

참가 물질

3

반응물 2

HCID 80011,3-DibromopropaneHCID 135829385n-(4-(6-Cyano-7-hydroxy-4-quinolyl)oxy-2-chlorophenyl)-n'-cyclopropylurea

생성물 1

HCID 22936714n-(4-((7-(3-Bromopropoxy)-6-cyano-4-quinolyl)oxy)-2-chlorophenyl)-n'-cyclopropylurea수율 15.6%

실험 절차

The title compound (129 mg, 0.250 mmol, 15.6%) was obtained as light brown crystals from an N-(4-(6-cyano-7-hydroxy-4-quinolyl)oxy-2-chlorophenyl)-N′-cyclopropylurea crude product (500 mg, 1.60 mmol) and 1,3-dibromopropane, by the same procedure as in Example 7.

출처 및 근거

ORD 기록
ord-af2cde056fce470494374870345e7296
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253286B2

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