Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → Benzyl N-(3-hydroxypropyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 3-Amino-1-propanol | HCID 9086 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Benzyl N-(3-hydroxypropyl)carbamate | HCID 562256 | 90.5% |
반응 단계
To a mixture of 3-aminopropan-1-ol (5.0 g, 67 mmol), Na2CO3 (8.8 g, 83 mmol) in THF (40 mL) and H2O (130 mL) at 0° C. was added Cbz-Cl (14.8 g, 87 mmol). The reaction mixture was stirred (RT, 1 h). Water (500 mL) and CH2Cl2 (500 mL) were added, and the layers were separated. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel chromatography (PE:EtOAc, 5:1) to afford benzyl 3-hydroxypropylcarbamate as a white solid (12.6 g, 90.5%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846972B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-15d10ead0c554d5d9ce2ae92b7fb8a25 |
| 출처 메모 | uspto-grants-2014_09 |