2-Methoxybenzaldehyde → 1-[2,5-Bis(2,2,2-trifluoroethoxy)phenyl]-3-(2-methoxyphenyl)-2-propen-1-one

HRID 853932

반응식

HRID 853932 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[CH:22](=O)[C:23]1[C:24]([O:29][CH3:30])=[CH:25][CH:26]=[CH:27][CH:28]=1>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[O:29][CH3:30]

참가 물질

3

반응물 2

HCID 86582-MethoxybenzaldehydeHCID 27360731-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one

생성물 1

HCID 914861501-[2,5-Bis(2,2,2-trifluoroethoxy)phenyl]-3-(2-methoxyphenyl)-2-propen-1-one

실험 절차

The title compound was prepared by heating a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and o-anisaldehyde (77 ul, 0.633 mmol) similar to Example 1 and isolated as a yellow solid (107 mg, 39%). 1H NMR (CDCl3): 8.03 (d, J=15.9 Hz, 1H), 7.61 (dd, J=1.4, 7.7 Hz, 1H), 7.44 (d, J=16.2 Hz, 1H), 7.40-7.34 (m, 1H), 7.25 (d, J=3.3 Hz, 1H), 7.09 (dd, J=3.0, 8.7 Hz, 1H), 7.00-6.94 (m, 2H), 6.92 (d, J=9.3 Hz, 1H), 4.42-4.32 (m, 4H), 3.86 (s, 3H).

후처리

  1. temperatureby heating

출처 및 근거

ORD 기록
ord-0b74a2b98a9b40c3be3317e973d786b3
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07256219B2

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