1-(2,5-Bis(2,2,2-trifluoroethoxy)phenyl)ethan-1-one → 1-[2,5-Bis(2,2,2-trifluoroethoxy)phenyl]-3-[3-fluoro-4-(trifluoromethyl)phenyl]prop-2-en-1-one
반응식
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH:7]=[CH:6][C:5]=1[O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[O:3].[F:22][C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][C:30]=1[C:31]([F:34])([F:33])[F:32])[CH:26]=O>>[F:21][C:18]([F:19])([F:20])[CH2:17][O:16][C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])=[CH:9][C:4]=1[C:2](=[O:3])[CH:1]=[CH:26][C:25]1[CH:28]=[CH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[C:23]([F:22])[CH:24]=1참가 물질
3
실험 절차
The title compound was prepared from a mixture of 2,5-bis(2,2,2-trifluoroethoxy)acetophenone (200 mg, 0.633 mmol) and 3-fluoro-4-(trifluoromethyl)benzaldehyde (91 ul, 0.633 mmol) similar to Example 18 as a yellow solid (164 mg, 53%). 1H NMR (CDCl3): 7.65-7.60 (m, 2H), 7.52 (d, J=15.9 Hz, 1H), 7.43-7.37 (m, 2H), 7.32 (d, J=3.3 Hz, 1H), 7.15 (dd, J=3.3, 8.7 Hz, 1H), 6.92 (d, J=9.0 Hz, 1H), 4.45-4.32 (m, 4H).
출처 및 근거
- ORD 기록
- ord-b094aaf4b1984c7290a698dc80fc3067