Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Pyridine-2-carboxylic acid [2-(4-nitro-phenyl)-3H-imidazo[4,5-c]pyridin-6-yl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Picolinoyl Chloride Hydrochloride | HCID 135033 | — |
| 반응물 | 2-(4-Nitro-phenyl)-3H-imidazo[4,5-c]pyridine-6-ylamine | HCID 58932918 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Pyridine-2-carboxylic acid [2-(4-nitro-phenyl)-3H-imidazo[4,5-c]pyridin-6-yl]-amide | HCID 58932934 | 31.6% |
반응 단계
A solution of amine 8 (0.145 g, 0.57 mmol) and picolinoyl chloride hydrochloride (0.180 g, 1.01 mmol) in dry pyridine (5 ml) was stirred at room temperature overnight. After addition of water the brown solid was filtered and passed through a SiO2 gel, eluting with CH2Cl2: MeOH (100:5) affording the desired product 21 (0.065 g, 31%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07256287B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-11d3075d86b149faa2357d917b9e7f11 |
| 출처 메모 | uspto-grants-2007_08 |