Heptanoic Acid → N-(Cyclohexylmethyl)heptanamide

참여 물질

역할	이름	HCID	투입량
반응물	Heptanoic Acid	HCID 8094	—
반응물	Cyclohexanemethylamine	HCID 76688	—
반응물	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
촉매	4-(Dimethylamino)pyridine	HCID 14284	—
용매	Dichloromethane	HCID 6344	—
생성물	N-(Cyclohexylmethyl)heptanamide	HCID 68856580	92%

반응 단계

To a solution of aminomethylcyclohexane (0.34 g, 3.0 mmol) in methylene chloride (30 mL) was added heptanoic acid (0.39 g, 3 mmol) and DMAP (0.37 g, 3.0 mmol) followed by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.57 g, 3.0 mmol) and the reaction mixture was stirred at room temperature overnight. The mixture was diluted with methylene chloride (100 mL), and the organic phase was washed with 5% HCl (3×75 mL), aqueous NaHCO3 (75 mL) and brine (75 mL), and dried over Na2SO4. Concentration in vacuo afforded 0.62 g (92%) of an oil, which then crystallised.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07256307B2
출처 데이터셋	uspto-grants-2007_08
ORD ID	ord-e7509eeef28946b3a4a7454ed2a35a46
출처 메모	uspto-grants-2007_08