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Potassium Carbonate → (R)-5-Chloro-7-[1,1-dimethyl-2-(2-trifluoromethyloxiranyl)-ethyl]-2,3-dihydrobenzofuran

HRID 854170
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HRID 854170 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]([CH3:29])([CH3:28])[CH2:12][C@:13]([CH2:19]SC2C=CC(C)=CC=2)([OH:18])[C:14]([F:17])([F:16])[F:15])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.F[B-](F)(F)F.C[O+](C)C.C(=O)([O-])[O-].[K+].[K+].C(=O)(O)[O-].[Na+]>ClCCl.O>[Cl:1][C:2]1[CH:3]=[C:4]([C:11]([CH3:28])([CH3:29])[CH2:12][C@:13]2([C:14]([F:17])([F:15])[F:16])[CH2:19][O:18]2)[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1
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참가 물질

7

반응물 4

HCID 11430Potassium CarbonateHCID 516892Sodium BicarbonateHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 69419561(S)-4-(5-chloro-2,3-dihydrobenzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-p-tolylsulfanylmethylpentan-2-ol

생성물 1

HCID 11638349(R)-5-Chloro-7-[1,1-dimethyl-2-(2-trifluoromethyloxiranyl)-ethyl]-2,3-dihydrobenzofuran수율 95%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

To a solution of (S)-4-(5-chloro-2,3-dihydrobenzofuran-7-yl)-1,1,1-trifluoro-4-methyl-2-p-tolylsulfanylmethylpentan-2-ol (1.43 g, 3.21 mmol) in 10 mL of anhydrous dichloromethane was added trimethyloxonium tetrafluoroborate (713 mg, 4.82 mmol). The resulting suspension was stirred at room temperature for 4.5 hours. A solution of potassium carbonate (1.33 g, 9.64 mmol) in 10 mL of water was then added. After 13 hours, the reaction mixture was poured into 40 mL of saturated aqueous sodium bicarbonate solution and extracted with three 50 mL portions of dichloromethane. The combined organic phases were washed with brine, dried over magnesium sulfate, filtered, and concentrated in vacuo. Purification by column chromatography with silica gel (eluted with 0%-2% EtOAc/hexanes) afforded the title compound as a clear oil (974 mg, 95%).

후처리

  1. waitAfter 13 hours
  2. extractionextracted with three 50 mL portions of dichloromethane
  3. washThe combined organic phases were washed with brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customPurification by column chromatography with silica gel (eluted with 0%-2% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-899c0cdea39447fc91ae5270a8c98a3f
출처 데이터셋
uspto-grants-2007_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07256300B2

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