2,2-Dimethyl-3-(piperidin-1-yl)propan-1-ol → [6-(2,2-Dimethyl-3-piperidin-1-yl-propoxy)-naphthalen-2-yl]-(4-methyl-piperidin-1-yl)-methanone

HRID 854243

반응식

HRID 854243 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]1)=[O:13])[CH:6]=[CH:5]2.[CH3:21][C:22]([CH3:32])([CH2:25][N:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[CH2:23]O>>[CH3:23][C:22]([CH3:32])([CH2:25][N:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[CH2:21][O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([N:14]1[CH2:15][CH2:16][CH:17]([CH3:20])[CH2:18][CH2:19]1)=[O:13])[CH:6]=[CH:5]2

참가 물질

3

반응물 2

HCID 2960142,2-Dimethyl-3-(piperidin-1-yl)propan-1-olHCID 58933892(6-Hydroxy-naphthalen-2-yl)-(4-methyl-piperidin-1-yl)-methanone2회

생성물 1

HCID 69062749[6-(2,2-Dimethyl-3-piperidin-1-yl-propoxy)-naphthalen-2-yl]-(4-methyl-piperidin-1-yl)-methanone

실험 절차

The title compound was synthesised from (6-hydroxy-naphthalen-2-yl)-(4-methyl-piperidin-1-yl)-methanone (intermediate B) and 2,2-dimethyl-3-piperidin-1-yl-propan-1-ol (commercially available) according to the procedure described for the synthesis of Example 1.

후처리

  1. customdescribed for the synthesis of Example 1

출처 및 근거

ORD 기록
ord-5b8f75d9397d44d9802d832b0a2c9862
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259158B2

연결된 노트

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