Potassium Carbonate → HCID 15546708, 화합물

HRID 854250노트

반응식

HRID 854250 반응식
[Cl:1][C:2]1[C:3]2[CH:11]=[CH:10][NH:9][C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:18]([O:20][C:21](=[O:26])[CH2:22][CH2:23][CH2:24]Br)[CH3:19]>CN(C=O)C>[CH2:18]([O:20][C:21](=[O:26])[CH2:22][CH2:23][CH2:24][N:9]1[C:4]2[N:5]=[C:6]([CH3:8])[N:7]=[C:2]([Cl:1])[C:3]=2[CH:11]=[CH:10]1)[CH3:19]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 76300Ethyl 4-bromobutyrateHCID 109208984-CHLORO-2-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE

생성물 1

HCID 15546708HCID 15546708, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
50 °C

실험 절차

0.5 g (3 mmol) of 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (prepared according to West and Beauchamp, J. Org. Chem. 26 (1961) 3809) was dissolved in 3 ml DMF and 2.06 g (15 mmol) of potassium carbonate was added to this solution. 0.431 ml (3 mmol) of 4-bromobutyric acid ethyl ester was added and the mixture was stirred at 50° C. for 45 minutes. The reaction mixture was diluted with 50 ml EE and washed three times with water, dried over MgSO4, filtered and the solvent was removed in vacuo. Yield: 0.8 g.

후처리

  1. additionThe reaction mixture was diluted with 50 ml EE
  2. washwashed three times with water
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-3b046e1d6b994a2b81a9222878e57b4d
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259159B2

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