Ammonia → (2-Aminopyrimidin-4-yl)(1,3-benzothiazol-2-yl)acetonitrile
반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([C:13]1[CH:18]=[CH:17][N:16]=[C:15](Cl)[N:14]=1)[C:11]#[N:12].[NH3:20]>C(O)C>[NH2:20][C:15]1[N:14]=[C:13]([CH:10]([C:2]2[S:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)[C:11]#[N:12])[CH:18]=[CH:17][N:16]=1참가 물질
4
반응 조건
- 온도
- 150 °C
실험 절차
A suspension of 1 (0.1 g, 0.35 mmol) in a 2M solution of ammonia in ethanol (10 ml) was heated up to 150° C. in a Parr vessel for 3 h. The solution was cooled down to r.t. and the yellow precipitate formed was filtered off then washed thoroughly with ethanol/water 1:1 and water. The precipitate was dried in vacuum at 40° C. affording 48 mg (51%) of the title compound as a yellow powder.
후처리
- temperatureThe solution was cooled down to r.t.
- customthe yellow precipitate formed
- filtrationwas filtered off
- washthen washed thoroughly with ethanol/water 1:1 and water
- customThe precipitate was dried in vacuum at 40° C.
출처 및 근거
- ORD 기록
- ord-e9dc4f0f2a5e462ea4308e39e7e503af
- 출처 데이터셋
- uspto-grants-2007_08
- 특허 번호
- US07259162B2
반응 노트
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