Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → Thioacetic acid S-[2-(4-fluoro-phenyl)-ethyl]ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 1-(2-Chloroethyl)-4-fluorobenzene | HCID 67622 | — |
| 반응물 | Potassium ethanethioate | HCID 23670855 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Thioacetic acid S-[2-(4-fluoro-phenyl)-ethyl]ester | HCID 23577239 | — |
반응 단계
A mixture of 2.4 g of 1-(2-chloro-ethyl)-4-fluoro-benzene, 30 mL of DMF, and 2.5 g of potassium thioacetate was stirred under nitrogen for 24 h. The mixture was diluted with 200 mL of water and extracted with 3×50 mL of dichloromethane. The combined organic layers were dried over magnesium sulfate and concentrated under reduced pressure. Drying under vacuum gave the product as an oil:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07259157B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-25effcfbf870484ba878e8e42f0a69ac |
| 출처 메모 | uspto-grants-2007_08 |