Water → 2-Methanesulfonylpyrimidine-4-carboxylic acid

HRID 854327

반응식

HRID 854327 반응식
[CH3:1][S:2][C:3]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][N:4]=1.[OH:12]OS([O-])=O.[K+].[OH2:18]>>[CH3:1][S:2]([C:3]1[N:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][N:4]=1)(=[O:12])=[O:18]

참가 물질

4

반응물 3

HCID 962WaterHCID 2957752-(Methylsulfanyl)pyrimidine-4-carboxylic acidHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 219922012-Methanesulfonylpyrimidine-4-carboxylic acid

실험 절차

To a solution of 2-(methylthio)pyrimidine-4-carboxylic acid (1.88 g (11.1 mmol) in THf (200 mL) was added Oxone (20.4 g, 33.1 mmol) in water (50 mL). The suspension was stirred for 24 h, then evaporated to dryness. The resulting white paste was extracted 5× each 100 mL EtOAc and 5% MeOH in EtOAc. The combined extracts were dried over anhydrous MgSO4, filtered and concentrated to give the sulfone as a white solid.

후처리

  1. customevaporated to dryness
  2. extractionThe resulting white paste was extracted 5× each 100 mL EtOAc and 5% MeOH in EtOAc
  3. dry with materialThe combined extracts were dried over anhydrous MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-00284f95bfa04d6b817e6ed041986761
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259157B2

연결된 노트

불러오는 중…