4-Hydroxybenzoic Acid → Benzyl 4-fluoro-4-{[(4-hydroxybenzoyl)amino]methyl}piperidine-1-carboxylate

반응식

[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][CH:3]=1.[NH2:11][CH2:12][C:13]1([F:29])[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH2:15][CH2:14]1>>[F:29][C:13]1([CH2:12][NH:11][C:6](=[O:8])[C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:10][CH:9]=2)[CH2:14][CH2:15][N:16]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH2:17][CH2:18]1

참가 물질

반응물 2

HCID 1354-Hydroxybenzoic Acid

HCID 22135645Benzyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate

생성물 1

HCID 58933555Benzyl 4-fluoro-4-{[(4-hydroxybenzoyl)amino]methyl}piperidine-1-carboxylate

실험 절차

4-Hydroxy benzoic acid was coupled to benzyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate according to the procedure for EXAMPLE 1.

출처 및 근거

ORD 기록: ord-f6a919f067b54d7d9af558bb4b026542
출처 데이터셋: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07259157B2

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