Formaldehyde → 2-(Pyrimidin-4-yl)ethanol

HRID 854347노트

반응식

HRID 854347 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][N:3]=1.[CH2:8]=[O:9]>CCOCC>[OH:9][CH2:8][CH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 189224-Methylpyrimidine

생성물 1

HCID 154753442-(Pyrimidin-4-yl)ethanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 4-methylpyrimidine (10 g, 106 mmol) and para-formaldehyde (3 g) was stirred in a 50 mL sealed capacity pressure vessel at 165° C. for 3.5 hours. After cooling, ether was added and the solvents evaporated to afford an oil. This was purified by silica column chromatography using a Flashmaster system, eluting with dichloromethane, then chloroform, ether, and finally ethyl acetate. The ethyl acetate fractions were evaporated to afford the title compound as an oil.

후처리

  1. customsealed capacity pressure vessel at 165° C. for 3.5 hours
  2. temperatureAfter cooling
  3. customthe solvents evaporated
  4. customto afford an oil
  5. customThis was purified by silica column chromatography
  6. washeluting with dichloromethane
  7. customThe ethyl acetate fractions were evaporated

출처 및 근거

ORD 기록
ord-24aa06d178004867a09c8cf2f8c473d2
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259163B2

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