6-chloro-N-[(1R)-1-phenylethyl]pyrazin-2-amine → N-[(1R)-1-Phenylethyl]-6-(4-phenyl-1H-imidazol-1-yl)pyrazin-2-amine

HRID 854452

반응식

HRID 854452 반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][C@@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[CH:5]=[N:4][CH:3]=1.[C:17]1([C:23]2[N:24]=[CH:25][NH:26][CH:27]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:11]1([C@H:9]([NH:8][C:6]2[CH:5]=[N:4][CH:3]=[C:2]([N:26]3[CH:27]=[C:23]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:24]=[CH:25]3)[N:7]=2)[CH3:10])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

3

반응물 2

HCID 587170826-chloro-N-[(1R)-1-phenylethyl]pyrazin-2-amineHCID 178418822HCID 178418822, 화합물

생성물 1

HCID 10315266N-[(1R)-1-Phenylethyl]-6-(4-phenyl-1H-imidazol-1-yl)pyrazin-2-amine수율 67%

실험 절차

In a procedure analogous to example 2, reaction of 6-chloro-N-[(1R)-1-phenylethyl]pyrazin-2-amine (180 mg, 0.77 mmol) and 4-phenylimidazole (122 mg, 0.85 mmol) furnished the product (176 mg, 67%).

출처 및 근거

ORD 기록
ord-91822874765642b682f6f9fc59917d42
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259179B2

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