Aluminium lithium hydride → HCID 58979003, 화합물

HRID 854581

반응식

HRID 854581 반응식
C[O:2][C:3](=O)[CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:12]=[N:13][C:14]([Cl:17])=[CH:15][CH:16]=2)[O:8][C:9]=1[CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[Cl:17][C:14]1[N:13]=[CH:12][C:11]([C:7]2[O:8][C:9]([CH3:10])=[C:5]([CH2:4][CH2:3][OH:2])[N:6]=2)=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 58765666[2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester

생성물 1

HCID 58979003HCID 58979003, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of [2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester (4.0 g, 15 mmol) from step B in THF (50 mL) is added a solution of lithium aluminum hydride in THF (1.0 M, 12.5 mL, 12.5 mmol) at 0° C. After 1 hr, the reaction is quenched by water and sodium hydroxide, filtered, concentrated. The crude material is used for the next step.

후처리

  1. customthe reaction is quenched by water and sodium hydroxide
  2. filtrationfiltered
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-af3bb7310b2d40ba982ffbe4852d0f55
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259175B2

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