Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 4-Benzyloxybenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 4-(Benzyloxy)benzoic acid | HCID 73880 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Benzyloxybenzamide | HCID 2726431 | — |
반응 단계
To a suspension of 4.565 g (20 mmol) 4-benzyloxybenzoic acid in 25 ml THF and 0.3 ml N,N-dimethylformamide was added dropwise at 0° C. a solution of 2.6 ml oxalyl chloride in 5 ml THF. Stirring was continued for 3 hours at room temperature, then the suspension was added slowly to a stirred ice-cold solution of concentrated aqueous ammonia. The organic solvent was evaporated, 100 ml water added and the precipitate isolated and dried in vacuo at 50° C. Yield: 4.29 g (94%) white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07259262B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-2827dab36d9049db89be51250fb6c366 |
| 출처 메모 | uspto-grants-2007_08 |