Ethyl (2E)-4,4,4-trifluoro-2-butenoate → ethyl 7-isopropyl-2-(trifluoromethyl)-2H-chromene-3-carboxylate

반응식

[OH:1][C:2]1[CH:9]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[CH2:13]([O:15][C:16](=[O:23])/[CH:17]=[CH:18]/[C:19]([F:22])([F:21])[F:20])[CH3:14]>>[CH:10]([C:8]1[CH:9]=[C:2]2[C:3]([CH:4]=[C:17]([C:16]([O:15][CH2:13][CH3:14])=[O:23])[CH:18]([C:19]([F:20])([F:22])[F:21])[O:1]2)=[CH:6][CH:7]=1)([CH3:12])[CH3:11]

참가 물질

반응물 2

HCID 5371261Ethyl (2E)-4,4,4-trifluoro-2-butenoate

HCID 101490244-Isopropyl salicylaldehyde

생성물 1

HCID 69517862ethyl 7-isopropyl-2-(trifluoromethyl)-2H-chromene-3-carboxylate

실험 절차

This salicylaldehyde (Step 1) was condensed with Ethyl-4,4,4-triflurocrotonate via a similar method to that of Example 4a, Step 1 producing the ethyl ester (8.21 g, 84%) as yellow solid. This ester was of suitable purity to use without further purification: ESLRMS m/z 315 (M+H).

후처리

customto use without further purification

출처 및 근거

ORD 기록: ord-09b32436f2ea4b819efcedb1dfc9c4f0
출처 데이터셋: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07259266B2

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