Sulfuric Acid → 2-(3-Methoxyphenyl)-2-methylpropanal

HRID 854955노트

반응식

HRID 854955 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]([CH3:13])([CH3:12])[C:10]#N)[CH:6]=[CH:7][CH:8]=1.[H-].C([Al+]CC(C)C)C(C)C.[OH:24]S(O)(=O)=O>C1COCC1.CCCCCCC.O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]([CH3:13])([CH3:12])[CH:10]=[O:24])[CH:6]=[CH:7][CH:8]=1

참가 물질

7

반응물 3

HCID 1118Sulfuric AcidHCID 101301932-(3-Methoxyphenyl)-2-methylpropanenitrileHCID 21225700Diisobutylaluminumhydride

생성물 1

HCID 132969932-(3-Methoxyphenyl)-2-methylpropanal

시약·촉매·용매 3

HCID 962Water용매HCID 8028Tetrahydrofuran용매HCID 8900Heptane용매

실험 절차

To a ice cold stirred solution of 2-(3-methoxyphenyl)-2-methylpropanenitrile (27.7 g, 158 mmoles) in 250 mL of THF was added dropwise diisobutylaluminum hydride in heptane (202 mL, 1.0M solution). The mixture was allowed to warm to room temperature overnight. After cooling, a solution of concentrated H2SO4 (21.5 mL) in 85 mL of water was cautiously added in small portions. The resulting mixture was partitioned between Et2O and water, the aqueous layer further extracted, and the combined organic extracts dried over Na2SO4, filtered, and evaporated to give 2-(3-methoxyphenyl)-2-methylpropanal, 21.7 g, as an oil.

후처리

  1. temperatureAfter cooling
  2. customThe resulting mixture was partitioned between Et2O and water
  3. extractionthe aqueous layer further extracted
  4. dry with materialthe combined organic extracts dried over Na2SO4
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-eacf6f42a2a24ce9a904d355680e7c5c
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259266B2

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