2-(3-Methoxyphenyl)-2-methylpropanenitrile → 2-(3-Hydroxyphenyl)-2-methylpropanenitrile

반응식

C[O:2][C:3]1[CH:4]=[C:5]([C:9]([CH3:13])([CH3:12])[C:10]#[N:11])[CH:6]=[CH:7][CH:8]=1.Cl.[NH+]1C=CC=CC=1>>[OH:2][C:3]1[CH:4]=[C:5]([C:9]([CH3:13])([CH3:12])[C:10]#[N:11])[CH:6]=[CH:7][CH:8]=1

참가 물질

반응물 2

HCID 101301932-(3-Methoxyphenyl)-2-methylpropanenitrile

HCID 21584435Pyridinium hydrochloride

생성물 1

HCID 125381552-(3-Hydroxyphenyl)-2-methylpropanenitrile

반응 조건

온도: 210 °C

실험 절차

A mixture of the title product of Example 106 Step 1 (520 mg, 2.97 mmoles) and pyridinium hydrochloride (2 g, 17.3 mmol) was stirred in an oil bath at 200-220 ° C. under a drying tube and so maintained for 3 h. After cooling, the mixture was partitioned between DCM and water, further extracted, and the combined organic extracts dried over Na2SO4, filtered, and evaporated to give the title compound, 416 mg, as a brownish oil.

후처리

temperatureso maintained for 3 h
temperatureAfter cooling
customthe mixture was partitioned between DCM and water
extractionfurther extracted
dry with materialthe combined organic extracts dried over Na2SO4
filtrationfiltered
customevaporated

출처 및 근거

ORD 기록: ord-5d8160982a1a47b19d8710e5afb1e6d1
출처 데이터셋: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07259266B2

반응 노트

불러오는 중…