Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenethylamine, m-trifluoromethyl- → [4-(1-Ethylcyclopropyl)-benzyl]-[2-(3-trifluoromethylphenyl)-ethyl]-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenethylamine, m-trifluoromethyl- | HCID 104223 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | (4-Cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine | HCID 69342889 | — |
| 반응물 | 4-(1-Ethylcyclopropyl)benzaldehyde | HCID 86093733 | — |
| 생성물 | [4-(1-Ethylcyclopropyl)-benzyl]-[2-(3-trifluoromethylphenyl)-ethyl]-amine | HCID 69342153 | — |
반응 단계
The title compound was synthesized in analogy to (4-cyclopropylbenzyl)-[2-(4-fluoro-3-trifluoromethylphenyl)-ethyl]-amine (described in example S53) using 4-(1-ethylcyclopropyl)-benzaldehyde (124 mg, 0.71 mmol), 2-(3-trifluoromethylphenyl)-ethylamine (135 mg, 0.71 mmol) and sodium borohydride (40 mg, 1.07 mmol). The desired product was isolated without further purification as a colorless oil. MS (ISP) 348.5 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07259183B2 |
| 출처 데이터셋 | uspto-grants-2007_08 |
| ORD ID | ord-2f54efa0a4214992bdee66902dfb5de1 |
| 출처 메모 | uspto-grants-2007_08 |