Triethylamine → 7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].Cl.[CH:15](N)=N.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][CH:15]=[N:13][S:10](=[O:11])(=[O:12])[C:3]=2[CH:4]=1참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
There is stirred for 1 night at 80° C. a suspension of 3.0 g of 2-amino-5-methoxybenzene-sulphonamide in the presence of 1.31 g of formamidine hydrochloride and 2.27 ml of triethylamine in 50 ml of toluene. The toluene is evaporated off in vacuo. The residue is taken up in water and the precipitate is filtered off.
후처리
- customThe toluene is evaporated off in vacuo
- filtrationthe precipitate is filtered off
출처 및 근거
- ORD 기록
- ord-4010f2f35f384bf2903d5735616940d8
- 출처 데이터셋
- uspto-grants-2007_08
- 특허 번호
- US07262189B2
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