Ethanol → Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

HRID 855576노트

반응식

HRID 855576 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([OH:16])=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[CH2:17](O)[CH3:18]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][CH:10]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:9]2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 702EthanolHCID 29126521-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

생성물 1

HCID 21935588Ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate

반응 조건

온도
0 °C

실험 절차

1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (unknown amount) was dissolved in 20 ml ethanol and cooled to 0° C. HCl gas was bubbled into the solution until the solution became red in color. The reaction was allowed to warm to room temperature and stir overnight. The solvent was removed to yield ethyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate (M+1=251.93).

후처리

  1. customHCl gas was bubbled into the solution until the solution
  2. temperatureto warm to room temperature
  3. customThe solvent was removed

출처 및 근거

ORD 기록
ord-ddf6368c380f455281066ed5d12c0df0
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262198B2

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