Methylamine → Methyl((1-methylpiperidin-3-yl)methyl)amine

HRID 855598

반응식

HRID 855598 반응식
Cl[CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH3:9])[CH2:4]1.[CH3:10][NH2:11]>C(O)C>[CH3:10][NH:11][CH2:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH3:9])[CH2:4]1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 1036743-(Chloromethyl)-1-methylpiperidine

생성물 1

HCID 16640588Methyl((1-methylpiperidin-3-yl)methyl)amine

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of 3-(chloromethyl)-1-methylpiperidine (9.2 g, 50 mmol) (U.S. Pat. No. 6,184,338, example 5) and 33% methylamine in ethanol (60 mL) in ethanol (30 mL) was heated in a sealed vessel at 100° C. for 17 hours. The reaction mixture was concentrated in vacuo and diluted with water before being extracted into dichloromethane and dried over magnesium sulphate. The reaction mixture was filtered and concentrated in vacuo to yield the title product, 8.2 g.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water
  3. extractionbefore being extracted into dichloromethane
  4. dry with materialdried over magnesium sulphate
  5. filtrationThe reaction mixture was filtered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-38f5bbda7a9440e8b4853f15c4b7d2a2
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262192B2

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