Oxalyl chloride → 2-Chloro-4,5-difluorobenzoyl Isocyanate

HRID 855782노트

반응식

HRID 855782 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:14](Cl)=[O:15]>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:6]=[C:14]=[O:15])=[O:5]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 23171512-Chloro-4,5-difluorobenzamide

생성물 1

HCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Chloro-4,5-difluorobenzamide was dissolved in dichloromethane, mixed with 1.5 eq. of oxalyl chloride and heated to reflux for 16 hours. The reaction mixture was concentrated under high vacuum and employed in stage b without further purification.

후처리

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe reaction mixture was concentrated under high vacuum
  4. customemployed in stage b without further purification

출처 및 근거

ORD 기록
ord-731fb258ae464be8b902cd5ec5eb23e4
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262220B2

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