참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Divinyl sulfone | HCID 6496 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | methyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(3-aminopropylamino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate | HCID 86676591 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 86676592 | HCID 86676592 | 83.4% |
반응 단계
Vinylsulfonylethene (5.90 mg, 0.050 mmol) and triethylamine (6.96 μl, 0.050 mmol) were added to a mixture of methyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(3-aminopropylamino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate (15 mg, 0.025 mmol) in EtOH (1 mL). The reaction mixture was heated to 100° C. for 3 hours. The reaction mixture was concentrated under reduced pressure to provide the desired product as a brown solid (15 mg, 76%). LCMS: m/e 719.46 (M+H)+, 3.68 min (method 10).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08846647B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-9651d5b1da8f433cb811e2faa8c72009 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
