(2-Methyl-4-nitrophenyl)(pyridin-2-yl)methanol → (4-Amino-2-methylphenyl)(pyridin-2-yl)methanol

HRID 856600노트

반응식

HRID 856600 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[OH:12]>C(O)C.[C].[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[OH:12])=[C:2]([CH3:1])[CH:7]=1

참가 물질

4

반응물 1

HCID 11447916(2-Methyl-4-nitrophenyl)(pyridin-2-yl)methanol

생성물 1

HCID 11390249(4-Amino-2-methylphenyl)(pyridin-2-yl)methanol수율 57.7%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

(2-methyl-4-nitrophenyl)(pyridin-2-yl)methanol (0.83 g) was dissolved in ethanol (50 ml), and the solution was reduced by catalytic hydrogenation overnight with 10% palladium-carbon of 50% hydration (50 mg). The catalyst was removed, and the solvent of the filtrate was distilled off and the residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane), to give (4-amino-2-methylphenyl)(pyridin-2-yl)methanol (0.42 g) as colorless crystals.

후처리

  1. customThe catalyst was removed
  2. distillationthe solvent of the filtrate was distilled off
  3. customthe residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-252ad9f0929049c2acb66c8a599eb8a0
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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