Thionyl Chloride → HCID 22938786, 화합물

HRID 856644노트

반응식

HRID 856644 반응식
[CH2:1]([N:3]1[CH:7]=[N:6][N:5]=[C:4]1[CH2:8]O)[CH3:2].S(Cl)([Cl:12])=O>>[ClH:12].[Cl:12][CH2:8][C:4]1[N:3]([CH2:1][CH3:2])[CH:7]=[N:6][N:5]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 22938611(4-ethyl-4H-1,2,4-triazol-3-yl)methanol

생성물 1

HCID 22938786HCID 22938786, 화합물

실험 절차

To 4-ethyl-3-hydroxymethyl-4H-1,2,4-triazole (4.6 g), thionyl chloride (36 ml) was slowly added at 0° C. The mixture was heated to reflux for 1 hour, and concentrated under reduced pressure. To the residue was added ethyl acetate and ethanol, and the precipitated crystals were collected by filtration. The crystals were washed with ethyl acetate, to give 3-chloromethyl-4-ethyl-4H-1,2,4-triazole hydrochloride (4.22 g) as orange crystals.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 hour
  3. concentrationconcentrated under reduced pressure
  4. additionTo the residue was added ethyl acetate and ethanol
  5. filtrationthe precipitated crystals were collected by filtration
  6. washThe crystals were washed with ethyl acetate

출처 및 근거

ORD 기록
ord-72fe571441664a4e9be409866d900805
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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