2-[(4-Nitrophenyl)sulfanyl]pyridine → 4-[(Pyridin-2-yl)sulfanyl]aniline

HRID 856668노트

반응식

HRID 856668 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)(=O)C>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[S:10][C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

참가 물질

3

반응물 1

HCID 40533372-[(4-Nitrophenyl)sulfanyl]pyridine

생성물 1

HCID 189716604-[(Pyridin-2-yl)sulfanyl]aniline수율 90.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2-[(4-nitrophenylsulfanyl) pyridine (8.0 g) was dissolved in acetic acid (64 ml), and reduced iron (24 g) was added to the mixture, and then, the mixture was stirred for 16 hours at room temperature. The mixture was filtered with Celite, washed with ethyl acetate, the solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give 4-(2-pyridinylsulfanyl) aniline (6.3 g).

후처리

  1. filtrationThe mixture was filtered with Celite
  2. washwashed with ethyl acetate
  3. customthe solvent was removed under reduced pressure
  4. customthe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-30c13dac58ac4403b9d81748d32546b9
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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