2-Methoxy-4-nitrobenzenethiol → 4-Amino-2-methoxybenzene-1-thiol

HRID 856696노트

반응식

HRID 856696 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[SH:12]>C(O)(=O)C>[NH2:9][C:7]1[CH:6]=[CH:5][C:4]([SH:12])=[C:3]([O:2][CH3:1])[CH:8]=1

참가 물질

3

반응물 1

HCID 221487412-Methoxy-4-nitrobenzenethiol

생성물 1

HCID 193920294-Amino-2-methoxybenzene-1-thiol수율 52.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To 2-methoxy-4-nitrobenzenethiol (7.0 g) was added acetic acid (70 ml), reduced iron (21 g) was added to the mixture, and the mixture was stirred for 6 hours at room temperature. The mixture was filtered with Celite, and washed with ethyl acetate. The solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give 4-amino-2-methoxybenzenethiol (3.1 g).

후처리

  1. additionwas added to the mixture
  2. filtrationThe mixture was filtered with Celite
  3. washwashed with ethyl acetate
  4. customThe solvent was removed under reduced pressure
  5. customthe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-4082bcaf6bfe4ffeb801f5d3bf3cd149
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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