5-Nitro-2-[(2-pyridinylmethyl)sulfanyl]pyridine → 6-[(2-Pyridinylmethyl)sulfanyl]-3-pyridineamine

HRID 856710노트

반응식

HRID 856710 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:8][CH:9]=1)([O-])=O>C(O)(=O)C>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][S:10][C:7]1[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

참가 물질

3

반응물 1

HCID 695219185-Nitro-2-[(2-pyridinylmethyl)sulfanyl]pyridine

생성물 1

HCID 433014876-[(2-Pyridinylmethyl)sulfanyl]-3-pyridineamine수율 34.7%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

5-nitro-2-[(2-pyridinylmethyl)sulfanyl]pyridine (6.0 g) was dissolved in acetic acid (60 ml), reduced iron (18 g) was added to the mixture, and the mixture was stirred for 240 hours at room temperature. The mixture was filtered with. Celite, and washed with ethyl acetate. The solvent was removed under reduced pressure, and the obtained residue was purified by silica gel column chromatography, to give 6-[(2-pyridinylmethyl)sulfanyl]-3-pyridineamine (1.83 g).

후처리

  1. filtrationThe mixture was filtered with
  2. washCelite, and washed with ethyl acetate
  3. customThe solvent was removed under reduced pressure
  4. customthe obtained residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-e38a987beda240139b158a0f4703e373
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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