Thionyl Chloride → 2-(chloromethyl)-1-(2,2,2-trifluoroethyl)-1H-imidazole hydrochloride

반응식

O[CH2:2][C:3]1[N:4]([CH2:8][C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][N:7]=1.S(Cl)([Cl:15])=O>>[ClH:15].[Cl:15][CH2:2][C:3]1[N:4]([CH2:8][C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][N:7]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 22938562(1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl)methanol

생성물 1

HCID 229386722-(chloromethyl)-1-(2,2,2-trifluoroethyl)-1H-imidazole hydrochloride

반응 조건

온도: 90 °C

실험 절차

To 2-hydroxymethyl-1-(2,2,2-trifluoroethyl)imidazole (1.40 g) was added thionyl chloride (14 ml), and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature, the solvent was distilled off under reduced pressure and the obtained solid was washed with ethyl acetate, to give 2-chloromethyl-1-(2,2,2-trifluoroethyl)imidazole hydrochloride (1.63 g) as brown crystals.

후처리

customto be at room temperature
distillationthe solvent was distilled off under reduced pressure
washthe obtained solid was washed with ethyl acetate

출처 및 근거

ORD 기록: ord-1b1df1f3a7874d369d3e8bc843ef27c9
출처 데이터셋: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07262185B2

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