Thionyl Chloride → HCID 22938853, 화합물

HRID 856756노트

반응식

HRID 856756 반응식
[CH:1]1([CH2:4][N:5]2[CH:9]=[CH:8][N:7]=[C:6]2[CH2:10]O)[CH2:3][CH2:2]1.S(Cl)([Cl:14])=O>>[ClH:14].[Cl:14][CH2:10][C:6]1[N:5]([CH2:4][CH:1]2[CH2:3][CH2:2]2)[CH:9]=[CH:8][N:7]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 229387391-Cyclopropylmethyl-2-hydroxymethylimidazole

생성물 1

HCID 22938853HCID 22938853, 화합물

반응 조건

온도
90 °C

실험 절차

To 1-cyclopropylmethyl-2-hydroxymethylimidazole (2.50 g) was added thionyl chloride (25 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature, the solvent was distilled off under reduced pressure and the obtained solid was washed with ethyl acetate, to give 2-chloromethyl-1-cyclopropylmethylimidazole hydrochloride. (2.96 g) as brown crystals.

후처리

  1. customto be at room temperature
  2. distillationthe solvent was distilled off under reduced pressure
  3. washthe obtained solid was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-813269d41bda4f7791b86ff74507be63
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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