Thionyl Chloride → 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride

HRID 856761

반응식

HRID 856761 반응식
O[CH2:2][C:3]1[N:4]([CH3:8])[CH:5]=[CH:6][N:7]=1.S(Cl)([Cl:11])=O>>[ClH:11].[Cl:11][CH2:2][C:3]1[N:4]([CH3:8])[CH:5]=[CH:6][N:7]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 573612(1-methyl-1H-imidazol-2-yl)methanol

생성물 1

HCID 27954062-(chloromethyl)-1-methyl-1H-imidazole hydrochloride

반응 조건

온도
90 °C

실험 절차

To 2-hydroxymethyl-1-methylimidazole (874 mg) was added thionyl chloride (10 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was recrystallized from ethyl acetate, to give 2-chloromethyl-1-methylimidazole hydrochloride (1.15 g) as brown crystals.

후처리

  1. customto be at room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe obtained residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-55507ce07af64445b0909f7af6bd6c7e
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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